Cordyceps
- “These findings support the belief, long held in China, that Cordyceps sinensis has the potential to improve exercise capacity and resistance to fatigue. An additional study involving more subjects would be needed to provide convincing evidence of post-treatment differences between the two groups. Also, endurance exercise testing at a constant submaximal work rate would be necessary to verify a truly ergogenic effect”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/#B10
- “In conclusion, we have successfully confirmed that Cordyceps militaris induces fatigue recovery via activating AMPK and AKT/mTOR pathways and regulating serum hormone level. Our data provides experimental evidence in supporting clinical use of Cordyceps militaris as an effective agent against fatigue.” (Study on Mice)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553310/
- “Treatment of cells by Cordyceps sinensis (250 μg/mL) significantly attenuated the oxidative stress in hypoxia…Further, higher levels of antioxidant, anti-inflammatory mediators, namely, TGFβ, HO1, and MT levels in Cordyceps sinensis treated cells might also be responsible for tolerance of cells to hypoxia.”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770031/
- Suggests improvement of exercise performance & may contribute to wellness in healthy older subjects
https://pubmed.ncbi.nlm.nih.gov/20804368/
- Interaction with covid -19
https://pubmed.ncbi.nlm.nih.gov/35071937/
- Cordyceps militaris improves sperm production in SD rats
https://www.worldscientific.com/doi/epdf/10.1142/S0192415X08006296
- “CS and cordycepin can significantly stimulate in vitro and in vivo steroidogenesis in mouse Leydig cells through the activation, at least, of PKA pathway, highly suggesting functional enhancements in male reproduction.”https://www.sciencedirect.com/science/article/pii/S102194981630182X
Lions Mane
- "Therapeutic Potential of Hericium erinaceus for Depressive Disorder"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982118/
- "Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake"
https://pubmed.ncbi.nlm.nih.gov/20834180/
- "Extracts alter behavioral rhythm in mice" ... "The findings of the present study suggest that HE may serve as a functional food in the prevention and treatment of Alzheimer's disease and delayed sleep phase syndrome."
https://pubmed.ncbi.nlm.nih.gov/27544998/
- "Anti-fatigue activities of polysaccharides extracted from Lions Mane."
https://pubmed.ncbi.nlm.nih.gov/25574220/
- "Extracts from Hericium erinaceus relives inflammatory bowel disease by regulating immunity and gut microbiota."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689651/
- "Anti-tumor, anit-inflammatory and antiallergic effect of...Hericium erinaceus... A review of preclinical and clinical studies."
https://pubmed.ncbi.nlm.nih.gov/32397163/
- “The results obtained in this study suggest that Yamabushitake (Lions Mane) is effective in improving mild cognitive impairment”https://pubmed.ncbi.nlm.nih.gov/18844328/
- “Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities”https://pubmed.ncbi.nlm.nih.gov/25306354/
- “The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression.The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties. A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases.”https://pubmed.ncbi.nlm.nih.gov/26244378/
- “The pre-clinical and clinical studies have demonstrated that H. erinaceus significantly ameliorates depressive disorder through monoaminergic modulation, neurogenic/neurotrophic, and anti-inflammatory pathways, indicating the potential role of H. erinaceus as a complementary and alternative medicine for the treatment of depression.”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982118/
- The described anti-inflammatory, antioxidative, and immunostimulating properties in cells, animals, and humans seem to be responsible for the multiple health-promoting properties. A wide range of research advances and techniques are described and evaluated. The collated information and suggestion for further research might facilitate and guide further studies to optimize the use of the whole mushrooms and about 70 characterized actual and potential bioactive secondary metabolites to help prevent or treat human chronic, cognitive, and neurological diseases.”https://pubmed.ncbi.nlm.nih.gov/24266378/
- "Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment"
https://pubmed.ncbi.nlm.nih.gov/27816657/
Reishi
- General overview "Cancer...Immunostimulating...Antioxidant-rich... Viral and bacterial infections...Liver and Gastric Injury"
https://www.ncbi.nlm.nih.gov/books/NBK92757/
- Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372873/
- Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities
https://pubmed.ncbi.nlm.nih.gov/21213395/
- "Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms"
https://pubmed.ncbi.nlm.nih.gov/15525457/
- "Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3"
https://pubmed.ncbi.nlm.nih.gov/21887458/
- "Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cell"
https://pubmed.ncbi.nlm.nih.gov/15781230/
- "Extract of Ganoderma lucidum prolongs sleep time in rats"
https://pubmed.ncbi.nlm.nih.gov/22207209/
- "Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis"
https://pubmed.ncbi.nlm.nih.gov/34715778/
- "Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats"
https://clinphytoscience.springeropen.com/articles/10.1186/s40816-018-0086-7#Sec17
- "... exhibited that the AEGA and EEGA have substantial medicinal property via its CNS depressant, anxiolytic, and analgesic activity, all of the activity measured with the standard reference drug. This study suggests that the biological constituents present in the plant are worthy of further investigation and structure elucidation."
https://www.sciencedirect.com/science/article/pii/S2405580821001564
- "A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia"
https://pubmed.ncbi.nlm.nih.gov/15857210/
Turkey Tail
- Cancer Treatment
https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
- Anti-microbial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972825/
- Control of oral human papillomavirus (HPV) by medicinal mushrooms, Turkey Tail & Reishi a preliminary clinical tria
https://pubmed.ncbi.nlm.nih.gov/25271984/
- The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010034/
- Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells
https://www.hindawi.com/journals/tswj/2015/146378/
- "Preoperative administration of polysaccharide Kureha and reduced plasma transforming growth factor-β in patients with advanced gastric cancer: A randomized clinical trial"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471616/
-
"Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro"
https://link.springer.com/article/10.1007/s11130-013-0342-4